Phosphinooxazolines

Phosphinooxazolines (often abbreviated PHOX) are a class of chiral ligands used in asymmetric catalysis.

Methods exist for installing the phosphine ligand before the oxazoline and the reverse.

Substitutions include allylic alkylations (Tsuji-Trost reaction),[11] aminations,[12] and sulfonylations.

[13] Palladium complexes containing chiral phosphinooxazolines are efficient catalysts for the Heck reaction.

[14] [15] Pd-PHOX catalysts have also been used for intramolecular Heck reactions and examples exist where they have been shown to be superior to more common ligands such as BINAP.