The enzyme phosphogluconate dehydratase (EC 4.2.1.12) catalyzes the chemical reaction This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds.

The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming).

This enzyme participates in the Entner–Doudoroff pathway.

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.

This EC 4.2 enzyme-related article is a stub.