The period between this date and the end of the Sienese republic in 1558 saw the development of a unique style of art from the city state, showing tendencies towards some of the more ethereal properties of the golden age of Sienese art rather than the studied realism and veneration of classical aesthetics and principles which drove many artists within the more celebrated centres of Florence, Rome and Venice.
Orioli had a relatively short artistic career (he died aged 37, and was only active independently from 1480), but his work is nonetheless important in the context of Sienese art.
He uses pale hatching unrelated to the landscape or architecture to reinforce the contours of his figures in a way that is similar to Botticelli's St Zenobius panels in the National Gallery, London.
His figures have a characteristically Sienese mystical quality, but also show a careful adherence to the rules of human anatomy and perspective.
Orioli was stylistic similar to the contemporaries operating within his home city, as well as being related to the highly celebrated Florentine Botticelli, who he may have influenced.