The purépechas arrived to that region in 1480, and they dominated the town of Tzapotlán for some years, but before the Spanish conquest they were defeated by the indigenous of Zapotlán, Zacoalco, Sayula, and Colima in the Saltpeter War (1480-1510) (Guerra del Salitre).

This territory was discovered and conquered by the Captain Cristóbal de Olid with the aid of Juan Rodríguez de Villafuerte in early 1522 when they were sent there by Hernán Cortés to explore the western region of what is today known as Jalisco.

In 1598 the town of Santiago of Pivámoc was on the bank of a river, in a valley between the high hills.

Antonio Cañas escaped because frequently, in the church, he gave the orders to the insurgent movement.

In Pihuamo, Dr. Atl presented the chimerical city of the Universal Culture with the name of "Olinka".