In 1155 or 1156, the inhabitants of these and other nearby towns were moved by Guido Guerra, of the Guidi Counts, to a hill where a new settlement, Poggiobonizio, was established.

In 1484, Lorenzo de' Medici had a new settlement built in Poggiobonizio according to the Renaissance idea of the "Ideal City", protected by a fortress designed by Antonio and Giuliano da Sangallo.

In the neighbourhood are: The municipality is formed by the city of Poggibonsi and the towns and villages (frazioni) of Bellavista and Staggia Senese.

Other notable villages include Case Bolzano, Castiglioni, Cedda, Cinciano, Gavignano, Lecchi di Staggia, Luco, Montemorli, Papaiano, Piandicampi, Sant'Antonio del Bosco and Talciona.

'Bonipoggio', a take-off of Poggibonsi, is the title of a cardinal played by Roger Ashton-Griffiths, in the BBC TV series 'Father Brown' S4 Ep5 'The Daughter of Autolychus'.