Radicofani (Italian pronunciation: [radiˈkɔːfani]) is a comune in the Province of Siena in the Italian region Tuscany, located in the natural park of Val d'Orcia about 110 kilometres (68 mi) southeast of Florence and about 60 kilometres (37 mi) southeast of Siena.

Climate is characterized by relatively high temperatures and evenly distributed precipitation throughout the year.

Occupying the highest point of a hill, at 896 metres (2,940 ft), it was restored after the conquest from the Grand Duchy of Tuscany (1560–67).

It has two lines of walls: the external one has a pentagonal shape, while the inner one is triangular, with three ruined towers at each corner and a cassero (donjon) which can be visited.

Also by della Robbia is the precious Madonna with Saints at the high altar of the church of Sant'Agata.