Point Run is a 2.08 mi (3.35 km) long 1st order tributary to Little Wheeling Creek in Ohio County, West Virginia.

Point Run rises about 0.5 miles southeast of Point Mills, West Virginia, in Ohio County and then flows west to join Little Wheeling Creek at Roneys Point.

[3] Point Run drains 1.44 square miles (3.7 km2) of area, receives about 41.0 in/year of precipitation, has a wetness index of 284.29, and is about 74% forested.

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