The Pokotciminikew River is a tributary of the North Shore of the Kakospictikweak River, flowing into the territory of the town of La Tuque, in the administrative region of Mauricie, in Quebec, Canada.

The course of this river successively crosses the cantons of Pfister, Balete and Mathieu.

The surface of the Pokotciminikew River is usually frozen from mid-November to the end of April; however, safe ice circulation is generally from early December to late March.

The Pokotciminikew River originates at the mouth of an unidentified lake (length: 0.4 kilometres (0.25 mi), altitude: 534 metres (1,752 ft)) located in the township of Pfister, in Eeyou Istchee James Bay (municipality).

The mouth of this head lake is located at: From the mouth of the head lake, the course of the Pokotciminikew River flows entirely into forest area on 10.2 kilometres (6.3 mi) according to the following segments: The confluence of the Pokotciminikew River with the Kakospictikweak River is located at: The toponym "Rivière Pokotciminikew" was formalized on September 6, 1984 at the Commission de toponymie du Québec.