There is no specific treatment to get rid of this condition, but there are medications that can control the symptoms such as seizures, delayed development or weakened muscles as some of the noted effects.

[citation needed] BFPP was one of the first discovered forms of polymicrogyria to have a gene identified linking to the syndromes caused.

Symmetrical distribution is also evident in this form, but more distinctly, patients with BFPP were found to have atrophy of the cerebellum and brain stem, as well as bilateral white matter abnormalities.

The clinical characterizations of BPP "include pseudobulbar palsy with diplegia of the facial, pharyngeal and masticory muscles (facio-pharyngo-glosso-masticatory paresis), pyramidal signs, and seizures.

This form has been associated with IQ scores that range from average intelligence to mild intellectual disability, seizures, and cognitive slowing.

BGP tends to show excessively folded and fused gyri of an abnormally thin cerebral cortex, and an absence of the normal six-layered structure.

[4] Though it is difficult to make a predictable prognosis for children with the diagnosis of PMG, there are some generalized clinical findings according to the areas of the brain that are affected.

[citation needed] Rates of symptoms in PMG include 78% for epilepsy, 70% for global developmental delay, 51% for spasticity, 50% for microcephaly, 45% for dysmorphic features (e.g., abnormal facies or hand, feet, or digital anomalies), and 5% for macrocephaly.

[6] Association with the gene WDR62 (diffuse or asymmetric PMG) and SCN3A has also been identified,[7][8][9][3] as well as other ion channels such as KCN, CACNA, GRIN, and GABAR.

[5] Non-genetic causes include defects in placental oxygenation and in association with congenital infections, particularly cytomegalovirus, syphilis, and varicella zoster virus.

[4][additional citation(s) needed] Polymicrogyria is a disorder of neuronal migration, resulting in structurally abnormal cerebral hemispheres.

The Greek roots of the name describe its salient feature: many [poly] small [micro] gyri (convolutions in the surface of the brain).

[citation needed] The gene GPR56 is a member of the adhesion G protein-coupled receptor family and is directly related to causing Bilateral frontoparietal polymicrogyria, (BFPP)-6.

It is studied to provide information on the causes along with insight into the mechanisms of normal cortical development and the regional patterning of the cerebral cortex using magnetic resonance imagine, MRI.

GPR56 is observed to be important for myelinations due to a mutation in this gene results in reduced white matter volume and signal changes as shown in MRI's.

Although both can have physiological effects on the patient, it is hard to determine PMG as the direct cause because it can be associated with other brain malformations.

[13] Pathologically, PMG is defined as "an abnormally thick cortex formed by the piling upon each other of many small gyri with a fused surface.

Pachygria leads to the development of broad and flat regions in the cortical area, whereas the effect of PMG is the formation of multiple small gyri.

The resolution displays the multiple folds within the cortical area, which is continuous with the neuropathology of an infected patient.

[citation needed] Gross examination exposes a pattern of many small gyri clumped together, which causes an irregularity in the brain surface.

The important aspect to realize is PMG affects each patient differently and treatment options and mitigation techniques will vary.