In molecular biology, a polynucleotide (from Ancient Greek πολυς (polys) 'many') is a biopolymer composed of nucleotide monomers that are covalently bonded in a chain.
The sequence of DNA or RNA species for a given polynucleotide is the main factor determining its function in a living organism or a scientific experiment.
RNA is composed of purine and pyrimidine nucleotides, both of which are necessary for reliable information transfer, and thus Darwinian natural selection and evolution.
Nam et al.[2] demonstrated the direct condensation of nucleobases with ribose to give ribonucleosides in aqueous microdroplets, a key step leading to RNA formation.
Similar results were obtained using wet-dry cycles by Becker et al.[3] Fish derived polynucleotide is used in aesthetic medicine as a dermal filler.