They create high energy music, fusing conventional guitar music with synthesized and computer generated sound to create a unique mixture of punk and synthpop heavily inspired by the American bands Devo and the Tubes, as well as Japanese bands such as P-Model and Yellow Magic Orchestra.

The band has been noted for their extremely energetic live performances and their wild gimmicky outfits, notably their straight-bar sunglasses and trademark orange boiler suits stamped with a simple "P".

Another member named Kaneko joined within the early years of the band, but he left and was soon replaced by Kayo.

The band dropped the "POLY-X" names, and reduced to a trio, with new member Fumi on Bass Support on some of the tracks from Neu.

In 2000, Polysics signed to Ki/oon Records (a subsidiary of Sony Music Japan Inc.) and released their first major album Neu.

In 2003, Neu was released in the United States on Asian Man Records to rave reviews and great sales.

Vista was released on October 9, 2007 for Myspace Records exclusively for the United States, to mark the band's ten-year anniversary.

They covered Buck-Tick's "Sid Vicious on the Beach" for Parade II -Respective Tracks of Buck-Tick-, released on July 4, 2012.

In addition, the giant robot mascot from the cover of their "Lo-Bits" EP sports a battle helmet that resembles the same iconic dome.

While Polysics claim Devo as their most prevalent influence, other bands and artists that have influenced their music, are occasionally referenced in their album or song titles, and whose music has sometime been repurposed in similar ways include Neu!, Brian Eno, XTC, Yellow Magic Orchestra, P-Model (who they have opened for), Talking Heads, Sparks, The B-52's, King Crimson, Kraftwerk, Denki Groove, Nirvana, Man or Astroman, Spoozys, and David Bowie, Hikashu and Plastics.

Polysics have covered songs by Devo, Styx, Suzi Quatro, Plastics, The Ramones, The Knack, Soft Cell, Hikashu, Thin Lizzy, P-Model and Frank Sinatra and have been known to play Yes during their sound checks.

In 2020, Jonathan McNamara of The Japan Times listed For Young Electric Pop (2002) as one of the 10 Japanese albums worthy of inclusion on Rolling Stone's 2020 list of the 500 greatest albums of all time, describing it as "a top-tier Polysics record and an accessible introduction to a band unequaled in their ability to leave you grinning from ear to ear.

[8] In the text commentary to his 2006 album Dinosaurchestra, he says that the song "Neverending Hum" was inspired by Polysics and Devo.