[3] The article that introduced them also defined the concepts of attack, historical information, clinical evidence, paraclinical evidence, lesion typical of MS, remission, separate lesions and laboratory support, which are necessary to apply the criteria.
Based on this, the authors defined a set of rules that can yield five conclusions:[3] CDMS, LSDMS, CPMS, LSPMS or noMS.
[6] Two pathologically disseminated inflammatory demyelinating lesions should be considered MS even if they are silent.
[citation needed] As more knowledge about the underlying pathology of MS has been gathered, the concepts of subclinical, preclinical and CIS have been used together with the Poser original classification.
[8] After the second confirming attack the situation is referred to as CDMS (clinically defined multiple sclerosis).