Prentiss Mellen (October 11, 1764 – December 31, 1840) was a lawyer, politician, and jurist from Massachusetts and Maine.

He moved to Barnstable, where he worked as a tutor for the family of James Otis Jr., and studied law with Shearjashub Bourne.

Still not meeting with financial success, he briefly joined his brother's law practice in Dover, New Hampshire before finally settling in Biddeford in the Massachusetts District of Maine.

[5] Mellen served on the Massachusetts Governor's Council 1808–1809, 1817, and as a presidential elector in 1817.

[7] Mellen died in Portland on December 31, 1840, and was buried in its Western Cemetery.