[2][3] The Blue Hose athletic program is a member of the Big South Conference and competes in the NCAA Division I Football Championship Subdivision (FCS).

[6] Mark Cody, former head coach of American and Oklahoma, was named to lead the Blue Hose.

Presbyterian was the first South Carolina-based Division I school to sponsor wrestling since Clemson eliminated its program in 1995.

Hebron High School was the first woman to sign a National Letter of Intent with a Division I wrestling program.

Football: Bailey Memorial Stadium opened in 2002, seating 6,500; play takes place on Claude Crocker field (natural grass).

In 2021, football will make a transition to the Pioneer Football League Golf: The Arnold Palmer-designed Musgrove Mill Golf Club is a championship course located at the site of the Revolutionary War Battle of Musgrove Mill and is host to Blue Hose home competitions.

The Blue Hose athletics program also has the Templeton Strength and Conditioning Weight Room and the Kemper D. Lake M.D.