[1] Prickle is part of the non-canonical Wnt signaling pathway that establishes planar cell polarity.
[4] Prickle1 plays an important role in the development of the nervous system by regulating the movement of nerve cells.
[11] The relative levels of the alternate forms may be regulated and involved in the normal control of planar cell polarity.
[2] Gene knockdown of Prickle1 by shRNA or dominant-negative constructs results in decreased axonal and dendritic extension in neurons in the hippocampus.
[5] Prickle1 gene knockdown in neonatal retina causes defects in axon terminals of photoreceptors and in inner and outer segments.