Strabismus was originally identified as a Drosophila protein involved in planar cell polarity.
[1] Flies with mutated strabismus genes have altered development of ommatidia in their eyes.
The amino acid sequence and localization studies for Strabismus indicate that it is a membrane protein.
Prickle is another protein in the planar cell polarity signaling pathway.
[3] VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis.