Princess Antoinette was born on 3 March 1885 at Schloss Georgium near Dessau in Anhalt.

Her parents were Leopold, Hereditary Prince of Anhalt and Princess Elisabeth of Hesse-Kassel (1861-1955).

Princess Antoinette married Prince Frederick of Schaumburg-Lippe as his second wife in Dessau on 26 May 1909.

They had two sons: Prince Wilhelm Friedrich died in 1938 at the age of 25, when his bomber aircraft crashed during military exercises at Neubrandenburg.

[1] Princess Antoinette died in Dessau, then in the German Democratic Republic, on 3 April 1963.