She was the sixth child and the third daughter in the family of Prince Karl Christian of Nassau-Weilburg and his wife Carolina of Orange-Nassau.

Later, the family was supplemented by five younger children, of whom son Karl Wilhelm and daughters Amelia and Henrietta reached adulthood.

At the age of 17, she became the wife of Hereditary Count Karl Ludwig of Wied-Runkel, who soon turned 24.

In 1791, Christian Ludwig received the title of prince,[1] and passed away in October of the same year.

Since the marriage was childless, after the death of his younger brother in April 1824, the rights to the Wied-Runkel lands passed to Johann Carl August of Wied.