She had a particularly close relationship with her sisters Agnes and Marie Leopoldine, with whom she mostly lived together, even after her marriage, and with whom she conducted an extensive correspondence when they were not together.

She married on 9 November 1769 in Dessau Count Simon August of Lippe-Detmold (1727–1782), widower of her sister Marie Leopoldine, who had died in April that year.

She was involved in a number of administrative issues and she planned reforms in Lippe, some of which she managed to implement.

She had significant influence on her husband and became the mainstay of the reforms sought by Chancellor Hoffmann.

In 1775 she founded the "Patriotic Society" one of the oldest rural credit institutions in Germany.