Propionylation is a post-translational modification of proteins, in which a propionyl-group is added to a lysine amino acid of a protein.
Propionylation participates in crucial biological processes, including metabolic processes and cellular stress response.
[3] Histone propionylation is a mark of active chromatin.
Accumulation of propionyl-CoA leads to increased protein propionylation.
[5] In patients with propionic acidemia, a rare autosomal recessive metabolic disorder, propionyl-CoA levels elevated and increased propionylation,[6] which might contribute to the pathology in these patients.