In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells.

A 2012 research paper indicates a causal link between elevated levels of localized PGD2 and hair growth inhibition.

[4] Applied topically, the researchers found PGD2 prevents hair growth, and mice that were genetically inclined to produce higher levels of PGD2 had inhibited hair growth.

The paper suggested that inhibition of hair growth involved binding of PGD2 to a DP2 receptor, and that DP2 therefore would be a therapeutic target for androgenic alopecia in both men and women with hair loss and thinning.

[5] Because PGD2's relation to asthma has been known for several years, several drugs that seek to reduce the effect of PGD2 through blocking the DP2 are already in clinical trials.