PAR2 modulates inflammatory responses,[5] obesity,[6] metabolism,[7] cancers [8][9] and acts as a sensor for proteolytic enzymes generated during infection.

[20] In case of human airway and lung parenchyma PAR2 is responsible for increased fibroblasts proliferation[21] and elevation of IL‐6, IL‐8, PGE2 and Ca2+ levels.

[25][26][27] Functional selectivity occurs with PAR2, several proteases cleave PAR2 at distinct sites leading to biased signalling.

[28] Synthetic small ligands also modulate biased signalling leading to different functional responses.

[31] This article incorporates text from the United States National Library of Medicine, which is in the public domain.