1CXZ, 1URF, 2RMK, 4NKG, 4OTD, 4OTG, 4OTH, 4OTI5585320795ENSG00000123143ENSMUSG00000057672Q16512P70268NM_002741NM_213560NM_001199593NM_177262NP_002732NP_998725NP_001186522NP_796236Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene.

This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway.

The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton.

The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis.

Alternatively spliced transcript variants encoding distinct isoforms have been observed.