1FUJ565719152ENSG00000277804ENSG00000196415ENSMUSG00000057729P24158Q61096NM_002777NM_011178NP_002768NP_035308Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene.

[5] PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes.

Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides.

It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.

[6]