As a result, all chromosomes will find a single partner with which to pair at meiosis, and there will be no deleterious consequences for the progeny.
In translocation heterozygote, however, certain patterns of chromosome segregation during meiosis produce genetically unbalanced gametes that at fertilization become deleterious to the zygote.
In a translocation heterozygote, the two haploid sets of chromosomes do not carry the same arrangement of genetic information.
Depending on the arrangement of the four chromosomes on the metaphase plate, this normal disjunction of homologous produces one of two equally likely patterns of segregation.
Because of the unusual cruciform pairing configuration in translocation heterozygotes, nondisjunction of homologous centromeres occurs at a measurable but low rate.