The bridge is at the western terminus of Bulevar Miguel Pou, the main gateway to the Ponce Historic Zone.

The Art Deco bridge carries four lanes of vehicular traffic from the two-way Miguel Pou Boulevard.

[7] An 1818 map[a] of the city of Ponce recorded by historian Eduardo Neumann Gandia shows that the site currently occupied by Puente de los Leones was a regular cross-way over Rio Portugués between the eastern flatlands and the village of Ponce to the west.

911", by Otto Hilgard Tittmann (b.1850 - d.1938) of the U.S. Coast and Geodetic Survey and published by Julius Bien & Co Photo Lithographers, New York, New York, shows a bridge over Río Portugués at the road from Ponce to Guayama via Calle Cristina, namely today's (2018) Puerto Rico Highway 1.

[11] The bridge was rebuilt in 1990,[12] and reopened in 1992[13] at which point it was renamed Puente de los Leones as part of the festivities of the 300th anniversary of the founding of the city.

To its northeast is the prestigious neighborhood of La Alhambra, the first large upper class suburban expansion developed in Puerto Rico (early 1900s).

Parque Lineal Veredas del Labrador, runs along the banks of Río Portugués, under this bridge.