[3] This feedback system allows for rapid responses to changes in population cell density, eliminating the production of energy-costly molecules.

[4] It is believed that these RNAs, guided by a protein, Hfq, can mediate the destabilization of the quorum-sensing master regulators LuxR/HapR/VanT mRNAs.

[6] The unique type of regulation by Qrr RNA likely produces expression patterns that protein transcription factors cannot.

Abundance of Hfq limits qrr RNA binding, as the separate RNAs compete for its safeguarding behavior.

[2] In the event of deficiency in a single Qrr RNA, the other genes are upregulated to compensate for the loss, but can also have independent functions.

[2] This functional duality give plasticity to bacteria possessing these genes, allowing them to react accordingly to environmental and communal conditions.

Few AIs are produced when cell density is low, which leads to a phosphorylated LuxO, along with sigma factor 54, activating qrr1-5 expression.

[11] AmiL was found to be involved in virulence of P. aeruginosa, including mammalian cytotoxicity, biofilm formation, and motility.

Since the production of these factors taxes the cell, the rapid response regulation provided by Qrr RNA could be advantageous in energy-conserving repression.