The 2016 Titans offensive line was heralded as one of the best in the league, which blocked for DeMarco Murray as he led the American Football Conference (AFC) in rushing yards.

Spain started his first two postseason contests, playing in the Titans' upset comeback 22–21 road victory over the Kansas City Chiefs, blocking for Derrick Henry as he accounted for a then-franchise record 191 total yards, and then the Titans' 35–14 road uloss to the New England Patriots in the Divisional Round.

Spain notably blocked for Derrick Henry as he was named AFC Offensive Player of the Month for December.

[4] During the 2019 season, Spain would start in all 16 games for the Bills, playing every offensive snap, committing only four penalties and not allowing a single sack.

In the Wild Card Round against the Houston Texans, Spain started at left guard as the Bills lost in overtime by a score of 22–19 despite a 16–0 halftime lead.

[12] Spain was the starting left guard for Cincinnati in Super Bowl LVI, where, on what would prove to be the Bengals' final offensive play of the game, Spain missed the block on Los Angeles Rams defensive tackle Aaron Donald, allowing him to nearly sack quarterback Joe Burrow, forcing a last ditch pass to Samaje Perine which would fall short, resulting in a Bengals 23–20 loss.