4D9T, 4D9U, 4JG6, 4JG7, 4JG8, 4NUS, 4NW5, 4NW6, 5D9K, 5D9L6197110651ENSG00000177189ENSMUSG00000031309P51812P18654NM_004586NM_148945NM_001346675NP_004577NP_001333604NP_683747 protein S6 kinase, 90kDa, polypeptide 3, also s RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.

This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway.

The activity of this protein has been implicated in controlling cell growth and differentiation.

[5] Mutations in this gene have been associated with Coffin–Lowry syndrome (CLS).

[7] RPS6KA3 has been shown to interact with CREB-binding protein,[8] MAPK1[9][10] and PEA15.