[4][5] The three initial Radeon Instinct products were announced on December 12, 2016, and released on June 20, 2017, with each based on a different architecture.

[16] The MI300A and MI300X are data center accelerators that use the CDNA 3 architecture, which is optimized for high-performance computing (HPC) and generative artificial intelligence (AI) workloads.

The Zen 4 CPU cores are based on the 5 nm process node and support the x86-64 instruction set, as well as AVX-512 and BFloat16 extensions.

The MI300A supports PCIe 5.0 and CXL 2.0 interfaces, which allow it to communicate with other devices and accelerators in a heterogeneous system.

The MI300X is designed to accelerate generative AI applications, such as natural language processing, computer vision, and deep learning.

The MI6, MI8, and MI25 products all support AMD's MxGPU virtualization technology, enabling sharing of GPU resources across multiple users.

It supports the deep learning frameworks: Theano, Caffe, TensorFlow, MXNet, Microsoft Cognitive Toolkit, Torch, and Chainer.