Compared to the Radeon brand for mainstream consumer/gamer products, the Radeon Pro brand is intended for use in workstations and the running of computer-aided design (CAD), computer-generated imagery (CGI), digital content creation (DCC), high-performance computing/GPGPU applications, and the creation and running of virtual reality programs and games.

The card features 2 liquid cooled R9 Nano cores & was marketed strongly for both the running and creation of virtual reality content with the slogan "For Gamers Who Create and Creators Who Game".

In April 2017 AMD announced a new version of the Radeon Pro Duo for release the following month.

SSG stands for Solid State Graphics, and the card will couple AMD's Fiji core with solid-state storage to increase the frame buffer for rendering.

[6] Users will be able to add up to 1 TB of PCIe M.2 NAND flash memory to improve render and scrubbing times.

The Pro V series was announced in August 2018 with the Vega-based Radeon Pro V340, a dual-GPU flagship card for use in datacenter virtualization, supporting up to 32 virtual machines at a time,[18] as well as several other potential uses for Computer-aided design, general rendering tasks, and Desktop as a Service.

These cards, along with the Pro SSG, will use the new, non-toxic and energy efficient YInMn Blue, discovered by Mas Subramanian.

[25] The WX 9100 is particularly well-suited for mission critical workloads and complex scientific modeling because the ECC memory helps correct "single or double bit error as a result of naturally occurring background radiation.

[27] These appear to be Polaris 11 derived parts with 10-16 4th generation GCN compute units, providing between 1 and 1.86 TFLOPS of performance.

The Radeon Pro W5700, which is based on RDNA Architecture for desktop workstations, was officially released on November 19, 2019.

The first RDNA2 based W6000 series cards were officially announced on June 8, 2021 and launched in Q3 2021, with the AMD Radeon Pro W6800, W6600 and W6600M for mobile.

[40] The real-time GPU accelerated photo and video stitching program will complement AMD's virtual reality development platform.

While traditional photo stitching is not that much of a complex task, Project Loom aims to improve render times when tasked with the heavy workload of stitching together multiple high resolution angles to form a 360 degree VR experience, either to headsets or mobile devices.

[41] Using AMD's Direct GMA protocol, the software allows Radeon Pro graphics cards to work directly with video capture hardware to stitch together a 30 fps, 360 degree 4k resolution video from 24, 1080p cameras at 60 fps.

[42] The software is to be competitive with Nvidia's VRWorks 360 Video SDK, and is reportedly set to be made open-source through GPUOpen.

[43] The successor to FireRender, Radeon ProRender works with high-end graphics programs as an OpenCL photorealistic offline 3D renderer and raytracing engine.

[41] ProRender was released by AMD in June 2016 with support for Blender, 3D Studio Max, SolidWorks, and Maya.