[4][5] Muzyka co-founded BioWare, which was incorporated in 1995, with Greg Zeschuk and Augustine Yip, in the early 1990s after they earned their medical degrees at the University of Alberta.

[8] He completed his Medical Doctorate (MD) in 1992 from the University of Alberta, and subsequently obtained his specialization from the Canadian College of Family Physicians (CCFP) in 1994.

[20] He has also served as the Founding Chair of the University of Alberta Venture Mentoring Service since fall 2013,[21] a program intended to help develop, uplift and inspire University of Alberta student and alumni entrepreneurs by creating excellent mentorship experiences for both entrepreneurs and mentors.

[22] Muzyka served from 2014 to 2020 as a member of the University of Alberta Board of Governors, and as Chair of the Human Resources and Compensation Committee.

In 2009, he was chosen by IGN as one of the top 100 game creators of all time alongside BioWare co-founder Greg Zeschuk.