The last building used for Reading Central Catholic High School consisted of what was William H. Luden's "Bon-Air" mansion.

The Luden's mansion eventually became Reading Central Catholic High School in 1939 with an initial class of 75 students, and an addition was made to the building in 1941, bringing it to its current size.

Plans were made in 2008 to build a new school on land purchased by the Diocese of Allentown but were eventually canceled.

On September 3, 1976, dedication of new bleachers on the visitors' side at the athletic field in St. Lawrence took place before the home football opener against Reading High.

[4] The Central Catholic Boosters (parents of CCHS students) volunteered to maintain the complex.

From 1983 through 1999, the Central Catholic Cardinals had a .903 winning percentage in their gym, a tremendous home court advantage.

In the early 1970s, PCIAA schools started to join the Pennsylvania Interscholastic Athletic Association (PIAA).

District 3 Championships On November 11, 2023, a special exception was granted to a Brooklyn-based developer Reading Hill LLC to convert the former high school into a 78-unit apartment complex.