Faced with saying goodbye to their friends and their way of life, the boys rally the townspeople to fight back against the rich and powerful Native Americans.
While the adults remain naive, the four main characters run outside and stand in front of the Native Americans' bulldozers, blocking their path.
At the same time, however, the casino owner's son, Premise Running Thin, gets infected with SARS accidentally because he had shared a drink with one of the Chinese men, and none of the Native Americans' herbs are able to cure him.
He discovers the trailer-living white man's way to cure the illness is Campbell's chicken noodle soup, DayQuil, and Sprite, and hands the mixture to the people of South Park, who all recover.
Stan, visibly irritated at the new kid's presence, asks him who he is, and he responds that he is Alex Glick, a fan who was granted the opportunity to do a guest voice role.
Kyle tells him to leave, and Alex does so, breaking the fourth wall to say hello to his family before walking off-screen, ending the episode.
"Red Man's Greed", along with the fourteen other episodes from The Complete Seventh Season, were released on a three-disc DVD set in the United States on March 21, 2006.