Reg'lar Fellers is a long-running newspaper comic strip adapted into a feature film, a radio series on the NBC Red Network, and two animated cartoons.

Created by Gene Byrnes (1889–1974), the comic strip offered a humorous look at a gang of suburban children (who nevertheless spoke like New York street kids).

While working as a sports cartoonist with the New York Telegram, Byrnes created his cartoon panel It's a Great Life If You Don't Weaken which introduced the Reg'lar Fellers characters in 1917.

Reg'lar Fellers of America was an athletic organization founded by Clair F. Bee, the Director of Health Education at Long Island University.

Arthur Dreifuss' live-action feature Reg'lar Fellers (1941) stars Billy Lee as Pinhead Duffy and Carl "Alfalfa" Switzer as Bump Hudson.

The Reg'lar Fellers comedy radio series, sponsored by Jello, aired Sunday nights on NBC from June 8 to August 31, 1941, as a summer replacement for The Jack Benny Program.