After Thomas' death in London in 1811, the land (at what is now Jamisontown) was taken up by his son, John, also a surgeon, who had served under Admiral Horatio Nelson at the Battle of Trafalgar, and was knighted for his medical services to the Royal Navy by the prince regent of the United Kingdom, later King George IV, in 1813.

Sir John Jamison arrived in Sydney in 1814 and progressively established himself during the ensuing two decades as one of the colony's biggest and wealthiest land owners.

He later erected a multi-storey tweed mill on his extensive estate and established a dairy, a thoroughbred horse stud, ornamental gardens, a cemetery, and a school for the children of his work force.

Sir John died at Regentville House in 1844, aged 68, having lost much of his fortune in a severe economic downturn then afflicting the colony.

The area around the site of Regentville House has remained largely rural, if hemmed in somewhat by the modern residential suburbs of Jamisontown and Glenmore Park.

The most common religious affiliation was No Religion (31.4%), lower than the national average of 38.4%, followed by Catholic (29.6%), Anglican (20.3%), Not stated (6.2%) and Christian, nfd (2.4%).

[1] At a local government level, Regentville is part of the south ward of Penrith City Council, represented by Jim Aitken, Mark Davies, Karen McKeown, Susan Page and Gary Rumble.

At the state governmental level, it is part of the Electoral district of Badgerys Creek, represented by Liberal Tanya Davies.