Prior to European settlement, what is now Werrington Downs was home to the Mulgoa people who spoke the Darug language.

They hunted kangaroos and emus for meat, and gathered yams, berries and other native plants.

Shortly after the arrival of the First Fleet in Australia in 1788, an outbreak of smallpox decimated the local indigenous communities and made it easier for settlers to dispossess them of their land.

It became part of the Werrington estate belonging to his sister Mary Lethbridge and was run as a farm until the 1880s when subdivision began.

At the state level, it is part of the Electoral district of Londonderry, represented by Labor Party member Prue Car.