[1] Hesse was trained by the Angolan-born Jamaican Moravian pioneer woman teacher, Catherine Mulgrave who set up three girls’ specialist boarding schools at Osu, Abokobi and Odumase and was active in the women's Christian ministry in Christiansborg, Accra.

[1][5] Her sister, Pauline Hesse (1831–1909), was a trader whose husband, Alexander Worthy Clerk, a Jamaican Moravian missionary-educationalist co-founded the Salem School, Osu.

[16] In 1854, after the British authorities bombarded Osu using the naval vessel, “HMS Scourge”, over the refusal of indigenes to pay the poll tax, another brother John Hesse, fled inland to Akropong and engaged in petty trading, together with other Ga-Dangme trader–refugees who had also been displaced by the conflict.

[17][18][19][20] The castle school, originally opened in 1722 and owned by the Danes, was handed over to the Basel Mission after the Danish colonial administration sold its assets on the Gold Coast to British authorities in 1850.

[1] Thus, Regina Hesse was influential in shaping the framework for the girls’ education programme through her efficient management and administration of the school.

"[21] After arriving on the Gold Coast in 1854, he opened a hardware shop in Christiansborg, selling goods and building materials for the local burgeoning construction industry: ropes, wires, hammers, saws, nails, bolts, hinges and door handles.

[21] The trading company was originally financed by Basel patricians, industrialists and politicians such as Daniel Burckhardt, Karl Sarasin and Christoph Median-Burckhardt.

[1] Bertha Rottmann's second marriage ended in divorce while her sister, Theodora was widowed again in 1895 after her second husband, Hermann Lieb passed away.

[1] As an educator, she was both a teacher and a spiritual mentor to a generation of young Euro-African and Ga-Dangme women of Christiansborg and played a major role in increasing the female literacy rate in the town.