Regine Velasquez on screen and stage

[9][10] In 2002, she appeared in an episode of ABS-CBN's drama series, Maalaala Mo Kaya, playing an intellectually disabled woman who develops a romantic relationship with a younger man—a role that earned her the Star Award for Best Actress.

[3][11] That year, she also portrayed a mundane and undesirable mail sorter in the drama Ikaw Lamang Hanggang Ngayon,[12] which garnered her a Young Critics Circle nomination for Best Actress.

[13] In 2003, Velasquez starred with Christopher de Leon in the romantic comedy Pangarap Ko Ang Ibigin Ka and played Darna in the superhero film Captain Barbell.

[17][18] In 2008, she lent her voice to the eponymous character in the animated film Urduja,[19] and returned to television in the comedy series Ako si Kim Samsoon.

[24][25] Velasquez expanded her career into reality television talent shows, serving as a presenter on Star for a Night (2002), Pinoy Pop Superstar (2004), and The Clash (2018), and as a judge on StarStruck (2015) and Idol Philippines (2019).