Although centred on the Temple of Peace within the Imperial Fora, Regio IV was cut in two by the Clivus Suburanus.
To the north west, it was bordered by the Vicus Patricius, the Clivus Suburanus and the Servian Wall and included the Carinae.
To the south east, it was bordered by the Colosseum and the Roman Forum, and included the Imperial fora and the Suburra.
A measurement taken at the end of the 4th century recorded that the perimeter of the region was 13,000 Roman feet (approximately 3.84 km).
Finally it included the Sororium Tigillum, on the Vicus Cyprius, which the ancient Romans built to the memory of Horatius.