Established in 1994, the school offers a specialized science and mathematics-oriented curriculum tailored for academically adept adolescents.

They offer an advanced curriculum in Science, Math, and English, along with enriched programs and research opportunities not typically available in regular schools.

The building was initially constructed in the late 1950s by the United States Navy for the education of their dependent children and was originally named George Dewey Elementary School.

The Regional Science High School is situated within one of the Philippines' remaining natural rainforests in the Subic Bay Freeport Zone.

The existing school buildings were originally constructed for the education of U.S. naval officers' children during the American colonial occupation and have remained largely unchanged since then.