Reinforced lipids

They can be used for the protection of living cells by slowing the chain reaction due to isotope effect on lipid peroxidation.

[2] They include (the names of the reinforced deuterated versions are separated by a slash): Hydrogen is a chemical element with atomic number 1.

One of the most pernicious and irreparable types of oxidative damage inflicted by reactive oxygen species (ROS) upon biomolecules involves the carbon-hydrogen bond cleavage (hydrogen abstraction).

[6] The concept of using reinforced lipids to inhibit lipid peroxidation has been tested in numerous cell and animal models, including: A double-blind comparator-controlled Phase I/II clinical trial of using D2-linoleic acid ethyl ester (RT001) for Friedreich's ataxia, sponsored by Retrotope and Friedreich's Ataxia Research Alliance, was conducted to determine the safety profile and appropriate dosing for consequent trials.

[16] In 2020, the FDA granted orphan drug designation RT001 for the treatment of patients with progressive supranuclear palsy (PSP).

Polyunsaturated fatty acids (PUFA), normal and deuterated, for the synthesis of reinforced lipids. Hydrogen atoms (H) are explicitly shown where they are replaced with deuterium (D), at oxidation-prone bis-allylic (between double bonds) positions. "R" stands for "radical", for example, hydrogen or ester .