599557811ENSG00000148604ENSMUSG00000021804P47804Q9Z2B3NM_001012720NM_001012722NM_002921NM_001301692NM_001301694NM_021340NP_001012738NP_001012740NP_002912NP_001288621NP_001288623NP_067315RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the RGR gene.

Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.

[6] RGR-opsin preferentially binds all-trans-retinal,[8] which is the dominant form in the dark adapted retina, upon light exposure it is isomerized to 11-cis-retinal.

[9] Therefore, RGR-opsin presumably acts as a photoisomerase to convert all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates.

RGR-opsin is exclusively expressed in tissue close to the rods and cones, the retinal pigment epithelium (RPE) and Müller cells.

[15] This article incorporates text from the United States National Library of Medicine, which is in the public domain.