Rev-Erb

The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock.

[1][2] These proteins act as key regulators of clock gene expression through transcriptional repression of Bmal1.

Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including metabolic, endocrine, and immune pathways.

[3][4][5] In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D).

[6] The receptors are potential drug targets for non-alcoholic steatohepatitis.

Diagram showing how REV-ERB regulates circadian gene expression through the secondary loop of the circadian transcription/translation feedback loop (TTFL)