Despite many attempts by the Assyrian kings to resolve this issue, such as Sennacherib's destruction of Babylon and Esarhaddon's restoration of it, rebellions and insurrections remained common.

Sinsharishkun realized the threat a large-scale revolt posed and led a massive counterattack in person, successfully recapturing Uruk, one of Nabopolassar's main seats of power, in 623 BC.

[4] Nabopolassar may have ultimately been defeated and control of Babylonia might have been restored had it not been for a 622 BC revolt led by an Assyrian general (whose name remains unknown) in the empire's western provinces.

Shortly after Assur's fall, Sinsharishkun made his last attempt at a counterattack, rushing to rescue the besieged city of Rahilu, but Nabopolassar's army had retreated before a battle could take place.

[8] Four years later, in 609 BC, the Medo-Babylonian forces decisively defeated the last Assyrian king, Ashur-uballit II, ending the Neo-Assyrian Empire.