Rhems is an unincorporated community located on the boundary between Williamsburg County and Georgetown County, South Carolina, United States.

It is centered around the intersection of County Line Road (SC 51), Rhems Road, and Browns Ferry Road (SC 41), not far from Black Mingo Creek, and just south of the historic Willtown site.

Furnifold Rhem, Sr. (1820-1888) settled in this location in 1846 and acquired a large plantation.

He founded F. Rhem Co., changing the name to F. Rhem & Sons Company in 1886 when he was joined by his two sons, Durward Dudley (1862-1922) and Furnifold, Jr. (1864-1918).

[5][6] Charles Flint Rhem (January 24, 1901 - July 30, 1969), born in Rhems, South Carolina, was a professional baseball player and pitcher.