[5] Unlike other high-hardness synthetic materials, such as the c-BN, rhenium diboride can be synthesized at ambient pressure,[4] potentially simplifying a mass production.

However, the high cost of rhenium and commercial availability of alternatives such as polycrystalline c-BN, make a prospect of large-scale applications less likely.

[4] ReB2 can be synthesized by at least three different methods at standard atmospheric pressure: solid-state metathesis, melting in an electric arc, and direct heating of the elements.

In the arc-melting method, rhenium and boron powders are mixed and a large electric current is passed through the mixture, also in an inert atmosphere.

In the direct reaction method, the rhenium-boron mixture is sealed in a vacuum and held at a high temperature over a longer period (1,000 °C for five days).