Rhodanine is a 5-membered heterocyclic organic compound possessing a thiazolidine core.

[3] Rhodanines can also be prepared by the reaction of carbon disulfide, ammonia, and chloroacetic acid, which proceeds via an intermediate dithiocarbamate.

[4] Some rhodanine derivatives have pharmacological properties; for instance, epalrestat is used to treat diabetic neuropathy.

However, most are promiscuous binders with poor selectivity; as a result, this class of compounds is viewed with suspicion by medicinal chemists.

[5][6][7] Differing academic opinions exist concerning the correct use of PAINS filters, the necessity of the experimental confirmations of such properties, and many useful features of rhodanine derivatives.