It runs north and crosses the South Branch Pawtuxet River before turning east to form a concurrency with Rhode Island Route 117.

Route 33 splits off to the northeast and continues along the bank of the South Branch Pawtuxet River.

It forms a concurrency with Rhode Island Route 115, crosses over the river, leaves Route 115, and then continues north over the Pawtuxet River.

From the split with New London Avenue in Cranston to the Pawtuxet River, Route 33 runs on the Warwick/West Warwick town line.

Route 33 northbound runs in Warwick and Route 33 southbound runs in West Warwick.