[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction: Mutations in rhodopsin kinase are associated with a form of night blindness called Oguchi disease.
[10] The post-translational modification of GRK1 by farnesylation and α-carboxyl methylation is important for regulating the ability of the enzyme to recognize rhodopsin in rod outer segment disk membranes.
Rhodopsin kinase is encoded from the GRK1 gene, so a mutation in GRK1 can result in Oguchi disease.
Studies have shown that lack of rhodopsin kinase will result in photoreceptor cell death.
[19] When photoreceptors cells die, they will be detached from the retina and result in retinal degeneration.